Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Thyroid Gland01:23

The Thyroid Gland

3.6K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
3.6K
Metastasis02:30

Metastasis

5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
The Parathyroid Glands00:59

The Parathyroid Glands

1.9K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
1.9K
Folliculogenesis01:20

Folliculogenesis

630
Folliculogenesis is the development of ovarian follicles, the specialized structures within the ovarian cortex where oogenesis, or egg development, occurs. This process is essential for female reproductive health and begins during fetal development when primordial follicles are formed. Each primordial follicle comprises a primary oocyte in the center, surrounded by a single layer of squamous pre-granulosa cells. These follicles remain dormant in late prophase I of meiosis until triggered by...
630

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

[Dyshormonogenetic goiter in a patient with congenital hypothyroidism: clinical, morphological and genetic features].

Arkhiv patologii·2026
Same author

[Sclerosing mucoepidermoid carcinoma with eosinophilia of thyroid gland].

Arkhiv patologii·2023
Same author

[Algorithm for morphological diagnosis of neoplasms in the chiasmal-sellar region].

Arkhiv patologii·2021
Same author

[Limitation of possibilities of cytological diagnosis of papillary thyroid cancer at the pre-surgery stage].

Arkhiv patologii·2020

Related Experiment Video

Updated: Jun 9, 2025

Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

1.6K

[High-grade encapsulated follicular cell thyroid carcinomas].

A Yu Abrosimov1, A A Kuryshev2

  • 1Endocrinology Research Center, Moscow, Russia.

Arkhiv Patologii
|October 22, 2024
PubMed
Summary

The 2022 WHO classification includes high-grade follicular cell-derived thyroid cancers. This study examines two such aggressive thyroid carcinomas, noting their fibrous capsules and potential for indolent behavior.

Keywords:
encapsulated follicular cell tumorshigh grade carcinomathyroid

More Related Videos

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
07:01

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

21.0K
Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
06:08

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma

Published on: June 2, 2023

1.7K

Related Experiment Videos

Last Updated: Jun 9, 2025

Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

1.6K
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
07:01

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

21.0K
Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
06:08

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma

Published on: June 2, 2023

1.7K

Area of Science:

  • Oncology
  • Pathology
  • Endocrinology

Background:

  • The 2022 World Health Organization (WHO) classification of thyroid tumors introduces a new category for high-grade follicular cell-derived malignancies.
  • This group encompasses poorly differentiated and high-grade differentiated thyroid carcinomas.

Purpose of the Study:

  • To describe two cases of thyroid carcinoma exhibiting signs of high malignancy.
  • To discuss the characteristics of these tumors, including the formation of a distinct fibrous capsule.
  • To explore the heterogeneity within this high-grade tumor group and the potential for indolent behavior.

Main Methods:

  • Case study analysis of two thyroid carcinoma patients.
  • Histopathological examination of tumor characteristics, focusing on capsule formation and grade.
  • Review of clinical and pathological data in the context of the 2022 WHO classification.

Main Results:

  • Two thyroid carcinomas with features of high malignancy were identified.
  • Both cases demonstrated the formation of a self-generated fibrous capsule.
  • Tumor heterogeneity and potential for less aggressive behavior were observed despite high-grade features.

Conclusions:

  • The described cases highlight the complexity of high-grade follicular cell-derived thyroid carcinomas.
  • The presence of a fibrous capsule in high-grade tumors warrants further investigation.
  • Understanding tumor heterogeneity is crucial for predicting the clinical behavior of these aggressive thyroid malignancies.