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What are the early warning signs of myocarditis during the pathway of care?

Yasar Sattar1, Aimen Shafiq2, Sahithi Sharma3

  • 1Department of Cardiology, West Virginia University, Morgantown, WV, USA.

Expert Review of Cardiovascular Therapy
|October 22, 2024
PubMed

Insights

This review explores myocarditis, an inflammatory heart condition. It highlights the need for better biomarkers to aid in early diagnosis and treatment of myocarditis.

Area of Science:

  • Cardiology
  • Immunology

Background:

  • Myocarditis is heart inflammation leading to potential heart failure and impaired cardiac function.
  • Current diagnostic methods like endomyocardial biopsy and imaging are invasive and expensive.
  • There is a need for reliable biomarkers for accurate myocarditis diagnosis and prognosis.

Purpose of the Study:

  • To review the definition, clinical features, diagnostic markers, imaging, prognosis, and complications of myocarditis.
  • To identify reliable, accurate, and prognostically informative biomarkers for myocarditis.
  • To provide clinicians with tools for early diagnosis and treatment of myocarditis.

Main Methods:

  • Comprehensive literature search of PubMed, Embase, and Cochrane databases.
  • Inclusion of articles from inception up to January 1, 2024.
  • Review focused on diagnostic and prognostic biomarkers for myocarditis.

Main Results:

  • Myocarditis can cause significant cardiac remodeling, fibrosis, and dysfunction.
  • Existing diagnostic techniques present limitations in cost and invasiveness.
  • Biomarkers are crucial for understanding disease progression and guiding treatment.

Conclusions:

  • Developing and adopting novel diagnostic and prognostic biomarkers is essential for myocarditis management.
  • Biomarkers can enhance clinical understanding of myocarditis progression.
  • Early diagnosis and treatment, facilitated by biomarkers, can improve patient outcomes in myocarditis.
Abstract

Keywords:
Myocarditisbiomarkerscardiomyopathyheart failuremyocarditis prognosis

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