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Troxerutin effect on gastric ulcers induced by ketorolac in rats: Relation with oxidative stress

  • 0Department of Pharmacology, Faculty of Pharmacy, Damascus University, Damascus, Syria.
Heliyon +

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October 22, 2024

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October 22, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Troxerutin demonstrated antioxidant effects, reducing oxidative stress and improving gastric ulcer indices in rats. This study highlights its potential for preventing NSAID-induced gastric ulcers.

Area Of Science

  • Pharmacology
  • Gastroenterology
  • Oxidative Stress Research

Background

  • Non-steroidal anti-inflammatory drugs (NSAIDs) commonly cause gastric ulcers.
  • Free radicals play a key role in NSAID-induced gastric ulcer development.
  • Troxerutin possesses antioxidant and anti-inflammatory properties, with limited research on its gastroprotective effects.

Purpose Of The Study

  • To investigate the preventive effect of troxerutin on ketorolac-induced gastric ulcers in a rat model.
  • To evaluate the antioxidant activity of troxerutin in the context of NSAID-induced gastric damage.
  • To assess the impact of troxerutin on gastric inflammation and oxidative stress markers.

Main Methods

  • Twenty-nine rats were divided into Vehicle, Ketorolac (Keto), Troxerutin (150 or 200 mg/kg), and Misoprostol (Miso) groups.
  • Troxerutin and misoprostol were administered orally 1 hour before ketorolac.
  • Ulcer index, gastric inflammation, thiobarbituric acid reactive substance (TBARS) levels, and catalase activity were measured.

Main Results

  • Both troxerutin and misoprostol significantly improved ulcer indices compared to ketorolac.
  • Misoprostol reduced gastric inflammation, while troxerutin did not show a significant effect.
  • Ketorolac-induced gastric oxidative stress was reduced by both troxerutin and misoprostol.

Conclusions

  • Troxerutin exhibits antioxidant effects that contribute to the prevention of ketorolac-induced gastric ulcers.
  • This study provides the first evidence of troxerutin's antioxidant role in mitigating NSAID-induced gastric ulcers.
  • Troxerutin shows promise as a potential agent for preventing NSAID-related gastrointestinal side effects.

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