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Deciphering the role of miRNA-134 in the pathophysiology of depression: A comprehensive review

Yunkai Wang1, Yali Huang1, Xuexing Luo2

  • 1Faculty of Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau SAR, China.

Heliyon
|October 22, 2024
PubMed

Insights

MicroRNA-134 (miRNA-134) significantly impacts synaptic plasticity and neurotransmitter regulation, offering potential for depression diagnosis and targeted treatment. This research highlights miRNA-134

Area of Science:

  • Molecular Psychiatry
  • Neuroscience
  • Genomics

Background:

  • Depression remains complex and under-investigated.
  • MicroRNA-134 (miRNA-134) is a short non-coding RNA influencing mood, synaptic plasticity, and neuronal function.
  • miRNA-134 targets the 3' untranslated region (3'UTR) to inhibit gene translation.

Purpose of the Study:

  • To summarize the role of miRNA-134 in depression pathophysiology, diagnosis, and treatment.
  • To evaluate the existing literature on miRNA-134 and depression.
  • To assess the diagnostic and therapeutic potential of miRNA-134.

Main Methods:

  • Systematic review of 15 articles from English and Chinese databases.
  • Quality assessment using the Critical Appraisal Skills Program (CASP) tool.
  • Integration of genomic, transcriptomic, neuroimaging, and behavioral data analyses.

Main Results:

  • miRNA-134 significantly influences synaptic plasticity and neurotransmitter regulation (serotonin, dopamine).
  • miRNA-134 demonstrates high sensitivity and specificity as a diagnostic biomarker for depression.
  • miRNA-134 exhibits therapeutic potential for targeted depression treatment.

Conclusions:

  • miRNA-134 is crucial in depression pathogenesis, aiding early diagnosis.
  • miRNA-134 offers insights for developing targeted therapeutic strategies.
  • miRNA-134 represents a key target for personalized medicine in depression treatment.
Keywords:
DepressionHippocampusMicroRNAsSynaptic plasticitymiRNA-134

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