CCL20 chemokine and other proinflammatory markers after Ad26.COV2.S vaccination
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.This study found no significant changes in C-C motif ligand 20 (CCL20) or IL-6 after Ad26.COV2.S vaccination. However, C-reactive protein (CRP) levels and anti-SARS-CoV-2 antibodies did change, with CRP differences noted in hypertensive patients.
Area Of Science
- Immunology
- Vaccinology
Background
- Biomarkers of vaccine-induced immunity are crucial during pandemics like COVID-19.
- Assessing C-C motif ligand 20 (CCL20) alongside other inflammatory markers provides insights into immune responses.
Purpose Of The Study
- To determine CCL20 concentration post-Ad26.COV2.S vaccination and its correlation with inflammatory molecules and anti-SARS-CoV-2 antibodies.
- To investigate inflammatory and immunologic differences between hypertensive and non-hypertensive individuals post-vaccination.
Main Methods
- 84 subjects vaccinated with Ad26.COV2.S were studied.
- CCL20, IL-6, and CRP levels were measured pre-vaccination and at 7 and 14 days post-vaccination.
- Anti-SARS-CoV-2 IgG antibody concentrations were measured at 7 and 14 days post-vaccination.
Main Results
- No statistically significant changes in CCL20 or IL-6 concentrations were observed post-vaccination.
- Significant differences were found in C-reactive protein (CRP) (P = 0.006) and anti-SARS-CoV-2 IgG antibody (P < 0.001) levels over time.
- CCL20 did not correlate with IL-6, CRP, or anti-SARS-CoV-2 IgG antibody levels.
- Hypertensive subjects showed a statistically significant difference in CRP concentration (P = 0.025) over the three time points.
Conclusions
- The study did not demonstrate changes in CCL20 concentration after Ad26.COV2.S vaccination, potentially due to the study's timeframe.
- Further research into chemokine profiles following SARS-CoV-2 immunization is needed to identify specific response patterns to vaccines.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
