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Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

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Comparing CD10 Expression With the Clinicopathological Features and Hormone Status of Invasive Breast Cancer.

Aravindan Kumaravel¹, Muthuvel Esakki¹

¹Pathology, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS) Saveetha University, Chennai, IND.

|October 22, 2024

Summary

CD10 expression is significantly associated with lymphovascular invasion in invasive ductal carcinoma (IDC). This finding suggests CD10 may be a potential prognostic marker for breast cancer patients, though further research is needed.

Keywords:

cd10 marker immunohistochemistry(ihc)invasive ductal cell carcinoma prognosis stromal cd10

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Area of Science:

Oncology
Pathology
Cancer Research

Background:

Female breast cancer is the most common cancer globally and a leading cause of cancer mortality.
In India, breast and cervical cancers are the most prevalent among women.
Invasive ductal carcinoma (IDC) is a common type of breast cancer requiring further prognostic markers.

Purpose of the Study:

To analyze the expression of CD10 in invasive ductal carcinoma (IDC).
To correlate CD10 expression with clinicopathological features and hormone receptor status in IDC.
To investigate the potential of CD10 as a prognostic marker in IDC.

Main Methods:

Retrospective analysis of 42 IDC NST cases.
Assessment of clinicopathological parameters including age, tumor site, size, grade, lymph node, lymphovascular, and perineural invasion.
Evaluation of hormone receptor status (ER, PR, Her2Neu) and CD10 expression using immunohistochemistry.
Statistical correlation using the chi-square test.

Main Results:

CD10 expression was positive in 93% of IDC cases.
A significant positive correlation was observed between CD10 expression and lymphovascular invasion (p=0.006).
No significant relationship was found between CD10 expression and hormone status, tumor grade, or lymph node metastases.

Conclusions:

CD10 expression is significantly associated with lymphovascular invasion in IDC.
CD10 does not show a significant relationship with other clinicopathological parameters or hormone status.
Further studies are warranted to explore CD10's role as a prognostic marker for IDC.