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The association between circulating saturated fatty acids and thyroid function: results from the NHANES 2011-2012
Wei Zhao1, Xinnan Peng2, Yazhuo Liu2
1Department of Endocrinology and Metabolism, Central Hospital of Dalian University of Technology; Dalian Municipal Central Hospital, Dalian, Liaoning, China.
Frontiers in Endocrinology
|October 22, 2024
Summary
High saturated fatty acids (SFAs) link to thyroid function. This study found correlations between circulating SFAs and thyroid hormones, suggesting a need for further research into these connections.
Area of Science:
- Endocrinology
- Nutritional Science
- Biochemistry
Background:
- Excessive saturated fatty acids (SFAs) intake is linked to adverse health outcomes.
- Limited research exists on the relationship between circulating SFA levels and thyroid hormone regulation.
Purpose of the Study:
- To investigate the association between circulating SFA concentrations and thyroid parameters in adults.
- To explore potential links between SFAs and thyroid hormone levels and antibodies.
Main Methods:
- Utilized data from 579 participants in the National Health and Nutrition Examination Survey (NHANES) 2011-2012.
- Employed subgroup analyses and multivariable linear regression models.
- Examined eleven distinct SFA concentrations and various thyroid parameters.
Main Results:
- Subgroup analyses showed significant differences in thyroid stimulating hormone (TSH) across nine SFAs and total SFAs.
- Multivariable regression revealed positive correlations between certain SFAs and TSH, TT3, FT3, TPOAb, TgAb, Tg, FT3/FT4 ratio, and TT4RI.
- Negative correlations were found between certain SFAs and TT4, FT4, FT3/TT3 ratio, and TFQI.
Conclusions:
- Circulating SFAs are associated with various thyroid parameters.
- Further research is needed to understand the mechanisms underlying SFA-thyroid interactions.
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