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Efficacy of Bifidobacterium longum and Lactobacillus plantarum (NVP-1703) in Children With Allergic Rhinitis: A

Kyunguk Jeong1, Seok Won Jang2, Se-Ah Jeon1

  • 1Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea.

Journal of Korean Medical Science
|October 22, 2024
PubMed

Insights

This study found that probiotics containing Bifidobacterium longum and Lactobacillus plantarum significantly reduced allergic rhinitis symptoms and improved quality of life in children. The treatment was safe and well-tolerated, showing promising results for managing pediatric allergic rhinitis.

Area of Science:

  • Immunology
  • Microbiology
  • Pediatrics

Background:

  • Allergic rhinitis (AR) is a common condition in children.
  • Probiotics show potential for AR treatment, but evidence is mixed.
  • The safety and efficacy of specific probiotic strains need further investigation.

Purpose of the Study:

  • To evaluate the therapeutic effects of a Bifidobacterium longum and Lactobacillus plantarum mixture (NVP-1703) in children with perennial allergic rhinitis.
  • To assess the safety profile of NVP-1703 in the pediatric population.
  • To investigate the impact of NVP-1703 on allergic inflammatory markers.

Main Methods:

  • A randomized, double-blind, placebo-controlled trial was conducted.
  • Participants included children aged 6-19 years with perennial AR.
  • Treatment involved NVP-1703 (1 × 10^10 CFU/day) or placebo for 4 weeks, with symptom scores, quality of life, and inflammatory markers assessed.

Main Results:

  • NVP-1703 significantly reduced total nasal symptom scores (TNSS) and nasal symptom duration scores (NSDS) compared to placebo.
  • Quality of life improved, particularly regarding mouth breathing and itchy nose.
  • Reduced ratios of IL-4/IL-22 and IL-5/IL-22 were observed, indicating modulation of allergic inflammation.
  • No significant adverse events were reported with NVP-1703.

Conclusions:

  • Oral NVP-1703 effectively improves allergic rhinitis symptoms and quality of life in children.
  • The probiotic mixture modulates T helper 2 cytokine responses.
  • NVP-1703 presents a safe and effective therapeutic option for pediatric perennial allergic rhinitis.
Abstract

Keywords:
AllergyMicrobiotaNasal SymptomsProbioticsQuality of Life

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