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Regression of genetically determined polycystic kidney disease in murine organ culture

E D Avner, W E Sweeney, N P Piesco

Experientia

|January 15, 1986

Abstract:

Cystic kidneys from the mutant CPK strain of C57BL/6J mice were cultured in serum-free organ culture. During 120 h of incubation in chemically-defined medium, CPK cystic tubular changes underwent complete regression. Environmental factors regulate the expression of genetically determined polycystic kidney disease in this model.

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