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DIONYSUS: a database of protein-carbohydrate interfaces.

Aria Gheeraert1, Thomas Bailly1, Yani Ren1,2

  • 1Université Paris Cité and Université des Antilles and Université de la Réunion, INSERM, BIGR, DSIMB, F-75015 Paris, France.

Nucleic Acids Research
|October 22, 2024
PubMed
Summary
This summary is machine-generated.

DIONYSUS is a new database detailing protein-carbohydrate interactions. It offers structural, chemical, and functional data to advance understanding and drug design for these vital biological processes.

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Area of Science:

  • Biochemistry and Structural Biology
  • Bioinformatics and Computational Biology

Background:

  • Protein-carbohydrate interactions are crucial for numerous biological processes.
  • Dysregulation of these interactions is implicated in various diseases.

Purpose of the Study:

  • To introduce DIONYSUS, the first database specifically cataloging protein-carbohydrate interfaces.
  • To provide comprehensive annotations including structural, chemical, and functional properties.

Main Methods:

  • Development of a database integrating information on interaction nature, binding site composition, and biological function.
  • Implementation of search functionalities based on protein sequence/structure and carbohydrate binding site properties.
  • Inclusion of comparative analysis tools for interaction sites against known non-covalent interactions.

Main Results:

  • DIONYSUS offers exhaustive data on protein-carbohydrate interfaces.
  • Users can query the database using diverse criteria, including sequence, structure, and binding site characteristics.
  • The database facilitates comparison of interaction sites to infer function and specificity.

Conclusions:

  • DIONYSUS serves as a valuable resource for understanding general protein-carbohydrate interaction patterns.
  • It aids in annotating uncharacterized proteins and supports applications like carbohydrate-based drug design.
  • The database is freely accessible for research purposes.