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Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
Published on: January 20, 2022
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DIONYSUS: a database of protein-carbohydrate interfaces
Aria Gheeraert1, Thomas Bailly1, Yani Ren1,2
1Université Paris Cité and Université des Antilles and Université de la Réunion, INSERM, BIGR, DSIMB, F-75015 Paris, France.
Nucleic Acids Research
|October 22, 2024
Summary
DIONYSUS is a new database detailing protein-carbohydrate interactions. It offers structural, chemical, and functional data to advance understanding and drug design for these vital biological processes.
Area of Science:
- Biochemistry and Structural Biology
- Bioinformatics and Computational Biology
Background:
- Protein-carbohydrate interactions are crucial for numerous biological processes.
- Dysregulation of these interactions is implicated in various diseases.
Purpose of the Study:
- To introduce DIONYSUS, the first database specifically cataloging protein-carbohydrate interfaces.
- To provide comprehensive annotations including structural, chemical, and functional properties.
Main Methods:
- Development of a database integrating information on interaction nature, binding site composition, and biological function.
- Implementation of search functionalities based on protein sequence/structure and carbohydrate binding site properties.
- Inclusion of comparative analysis tools for interaction sites against known non-covalent interactions.
Main Results:
- DIONYSUS offers exhaustive data on protein-carbohydrate interfaces.
- Users can query the database using diverse criteria, including sequence, structure, and binding site characteristics.
- The database facilitates comparison of interaction sites to infer function and specificity.
Conclusions:
- DIONYSUS serves as a valuable resource for understanding general protein-carbohydrate interaction patterns.
- It aids in annotating uncharacterized proteins and supports applications like carbohydrate-based drug design.
- The database is freely accessible for research purposes.
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