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Updated: Jun 9, 2025
Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
Published on: April 6, 2012
Retraction Note: MiR-15a-3p suppresses the growth and metastasis of ovarian cancer cell by targeting Twist1
1Obstetrics and Gynecology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Abstract:
The article "MiR-15a-3p suppresses the growth and metastasis of ovarian cancer cell by targeting Twist1" by B. Fan, L.-P. Chen, Y.-H. Yuan, H.-N. Xiao, X.-S. Lv, Z.-Y. Xia, published in Eur Rev Med Pharmacol Sci 2019; 23 (5): 1934-1946-DOI: 10.26355/eurrev_201903_17232-PMID: 30915736 has been retracted by the Editor in Chief. The authors contacted the journal, claiming that, after carefully examining the published article, they found that two of the figures in the article were duplicates. They also stated that they did not have access to the original figures. Therefore, they requested the manuscript to be retracted. After the authors' email, the journal started an investigation and found that the article was also questioned on PubPeer (link: https://pubpeer.com/publications/3FA0DDA41DFC73C5E8E8E1C505DBAA). The journal's investigation uncovered a duplication between Figures 3D and Figure 6D. Consequently, the Editor in Chief mistrusts the results presented and has decided to retract the article. The authors have agreed upon the retraction. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/17232.
Insights
This ovarian cancer study is retracted due to duplicate figures, impacting the reliability of its findings on microRNA-15a-3p and Twist1. The authors and journal agreed on retraction after discovering data integrity issues.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Context:
- Ovarian cancer is a leading cause of cancer-related death in women.
- MicroRNAs (miRNAs) play crucial roles in cancer development and progression.
- Twist1 is a transcription factor implicated in cancer metastasis.
Purpose:
- To investigate the role of microRNA-15a-3p (miR-15a-3p) in suppressing ovarian cancer cell growth and metastasis.
- To identify Twist1 as a direct target of miR-15a-3p in ovarian cancer.
Summary:
- The article "MiR-15a-3p suppresses the growth and metastasis of ovarian cancer cell by targeting Twist1" has been retracted.
- Retraction was initiated by the authors due to duplicate figures (Figures 3D and 6D).
- The journal's investigation confirmed figure duplication, leading to mistrust in the presented results and retraction.
Impact:
- The retraction raises concerns about the validity of the study's conclusions regarding miR-15a-3p and Twist1 in ovarian cancer.
- This highlights the importance of rigorous data verification in scientific publishing.
- Researchers should exercise caution when referencing this retracted study.
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