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Homeostatic Imbalances:
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Related Experiment Video

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Ozone: complicated effects in central nervous system diseases.

Xu Zhang1, Shi-Jun Wang, Si-Cen Wan

  • 1Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.

Medical Gas Research
|October 22, 2024
PubMed
Summary

Ozone

Area of Science:

  • Biochemistry
  • Neuroscience
  • Toxicology

Background:

  • Oxidative stress is implicated in numerous diseases.
  • Ozone's dual nature: potent oxidant causing damage, yet therapeutic at low concentrations.
  • Evidence suggests ozone's medical potential beyond its toxicity.

Purpose of the Study:

  • To review ozone's mechanisms, therapeutic value in CNS diseases (ischemic stroke, Alzheimer's), and toxic effects.
  • To explore ozone's role in oxidative stress response and its potential as a therapeutic agent.
  • To assess the impact of antioxidants on ozone's effects.

Main Methods:

  • Literature review of animal experiments and clinical studies on ozone therapy.
  • Analysis of ozone's redox reactions and signaling pathways.

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  • Examination of ozone's effects on inflammation and amyloid-beta levels.

    • Main Results:

    • High ozone exposure or lack of antioxidants causes harm.
    • Low ozone concentrations with adequate antioxidants can reduce inflammation and amyloid-beta.
    • Ozone therapy shows potential for treating ischemic stroke and Alzheimer's disease.
    • Ozone improves tissue oxygenation and transmits oxidative stress signals.

    Conclusions:

    • Ozone exhibits therapeutic potential for central nervous system diseases, particularly ischemic stroke and Alzheimer's disease.
    • Adequate antioxidants are crucial for harnessing ozone's beneficial effects and mitigating toxicity.
    • Further research is required to establish optimal ozone dosage and efficacy.