Related Experiment Video

Updated: Jun 9, 2025

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing
08:59

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

Published on: January 12, 2021

8.2K

NeoTCR: An Immunoinformatic Database of Experimentally-supported Functional Neoantigen-specific TCR Sequences

Weijun Zhou1,2, Wenting Xiang3, Jinyi Yu2

  • 1Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.

Genomics, Proteomics & Bioinformatics
|October 22, 2024
PubMed

Insights

Neoantigen-specific T cell receptors (TCRs) are crucial for effective cancer immunotherapy. A new database, NeoTCR, unifies scattered data on these TCRs, aiding research and development.

Area of Science:

  • Immunology
  • Bioinformatics
  • Computational Biology

Background:

  • Neoantigen-based immunotherapy shows promise for long-lasting antitumor effects.
  • T cell receptor (TCR) recognition of neoantigens initiates antitumor responses.
  • Identifying specific TCRs from vast repertoires is challenging, with data currently fragmented.

Purpose of the Study:

  • To create a centralized, accessible database of neoantigen-specific TCR sequences.
  • To facilitate the retrieval and analysis of TCR data for cancer immunotherapy research.
  • To develop a tool that aids in the discovery and annotation of TCRs from sequencing data.

Main Methods:

  • Development of an immunoinformatic database (NeoTCR) integrating TCR sequences and neoantigen information.
  • Inclusion of data from experimentally supported studies across 18 cancer subtypes.
  • Creation of a user-friendly web interface for data browsing and querying.

Main Results:

  • NeoTCR provides a unified repository of neoantigen-specific TCR sequences and associated data.
  • The database supports interactive browsing, complex queries, and analysis of TCR clonotypes.
  • Includes tools for annotation, visualization, discovery of known TCRs, and exclusion of viral TCRs.

Conclusions:

  • NeoTCR serves as a valuable resource for researchers studying neoantigen-specific TCRs.
  • The database is expected to accelerate the development of novel neoantigen-based immunotherapies.
  • NeoTCR is publicly available and aims to streamline T cell receptor research in oncology.
Keywords:
CDR3DatabaseImmunotherapyNeoantigenT cell receptor

More Related Videos

Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles09:28

Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles

Published on: November 17, 2018

11.5K
Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain08:48

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain

Published on: October 25, 2016

8.4K

Related Concept Videos

Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
531
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
674