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Updated: Jun 9, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Curing Psoriasis.

Su M Lwin1, Shir Azrielant2, Juan He3

  • 1St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom; St John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, London, United Kingdom.

The Journal of Investigative Dermatology
|October 22, 2024
PubMed
Summary
This summary is machine-generated.

Psoriasis may be curable by restoring immune balance. A personalized approach combining biologics, advanced therapies, and lifestyle changes offers potential for long-term disease remission.

Keywords:
Advanced therapiesBiologicsCureLifestyle modificationPersonalized medicinePsoriasis

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Area of Science:

  • Immunology
  • Dermatology
  • Personalized Medicine

Background:

  • While cures are emerging for many diseases, psoriasis traditionally only achieves remission, often temporary, with biologic therapies.
  • Current treatments for severe psoriasis, including biologics, can lead to long-lasting disease suppression but relapse is common upon drug withdrawal.

Purpose of the Study:

  • To hypothesize that psoriasis is curable, moving beyond the traditional definition of remission.
  • To propose a novel therapeutic strategy for achieving a potential cure for psoriasis.

Main Methods:

  • Leveraging an improved understanding of psoriasis pathomechanisms.
  • Considering anecdotal evidence of long-term disease clearance following cell-based therapies.
  • Proposing a combinatorial, personalized medicine approach.

Main Results:

  • The study hypothesizes that psoriasis is curable based on current scientific understanding and anecdotal evidence.
  • A proposed therapeutic strategy aims to restore immune homeostasis for potential long-term disease resolution.

Conclusions:

  • Psoriasis may be curable by restoring immune homeostasis.
  • A combinatorial, personalized medicine strategy including early intervention with biologics, advanced therapeutics, and lifestyle modification is proposed.
  • This approach aims for a definitive cure rather than temporary remission.