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Remote ischemic periconditioning suppresses cardiac sympathetic activation in acute myocardial infarction: a

Takumi Kondo1, Masahiro Seo2, Tetsuya Watanabe2

  • 1Division of Cardiology, Osaka General Medical Center, Osaka, 558-8558, Japan. takumikondou2000@yahoo.co.jp.

European Journal of Nuclear Medicine and Molecular Imaging
|October 22, 2024
PubMed

Insights

Remote ischemic conditioning (RIPC) may suppress cardiac sympathetic nerve activity in ST-elevation myocardial infarction (STEMI) patients. This study found RIPC led to lower cardiac sympathetic nerve activity one year post-procedure in STEMI patients.

Area of Science:

  • Cardiology
  • Nuclear Medicine
  • Interventional Cardiology

Background:

  • Remote ischemic periconditioning (RIPC) shows cardioprotective benefits alongside percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI).
  • The impact of RIPC on cardiac sympathetic nerve activity in STEMI patients remains under investigation.

Purpose of the Study:

  • To investigate the effect of RIPC on cardiac sympathetic nerve activity in patients with STEMI undergoing emergent PCI.

Main Methods:

  • A prospective study assigned STEMI patients undergoing PCI to RIPC or a control group.
  • Cardiac sympathetic nerve activity was assessed using the washout rate (WR) of cardiac 123I-metaiodobenzylguanidine (123I-MIBG) imaging.

Main Results:

  • No significant difference in WR was observed between groups at discharge.
  • At 1-year follow-up, the RIPC group exhibited significantly lower WR (p=0.027) compared to the control group.
  • RIPC was associated with higher late uptake (p=0.021) and lower WR (p=0.013) in non-culprit lesions at 1 year.

Conclusions:

  • RIPC appears to suppress elevated cardiac sympathetic nerve activity in STEMI patients.
  • The suppressive effect is particularly noted in non-culprit coronary artery lesions.
Abstract

Keywords:
Cardiac 123I-MIBG imagingCardiac sympathetic nerve activityRemote ischemic periconditioningST-elevation myocardial infarctionWashout rate

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