The Latin American Society for Immunodeficiencies Registry

Area of Science:

• Immunology
• Pediatrics
• Public Health

Background:

• The Latin American Society of Immunodeficiencies (LASID) Registry was established in 2009.
• This is the first report detailing the entire LASID dataset, encompassing data from 2009 to 2022.

Purpose of the Study:

• To present a comprehensive analysis of the LASID Registry data.
• To understand the landscape of Inborn Errors of Immunity (IEI) in Latin America.

Main Methods:

• Utilized an online platform donated by the European Society of Immunodeficiencies (ESID).
• Collected demographic, clinical, and follow-up data from participating centers between April 2009 and December 2022.
• Included 9307 patients diagnosed with Inborn Errors of Immunity (IEI).

Main Results:

• Predominantly antibody deficiency (PAD) was the most frequent IEI type (60.35%).
• Selective IgA deficiency and Common Variable Immune Deficiency (CVID) were the most common diagnoses.
• Median age at diagnosis was 4.77 years, with a median diagnostic delay of 5.04 years.
• Omenn syndrome had the highest mortality rate (52.63%) among deceased patients.

Conclusions:

• This study provides crucial insights into IEI epidemiology in Latin America.
• Emphasizes the critical need for early diagnosis and timely treatment to improve patient outcomes.
• Highlights the value of robust data collection for advancing IEI care.