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Updated: Jun 9, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
Nitrogen Oxide (NO) in the Pathogenesis of Preeclampsia
V Yu Titov1, A N Osipov2, I V Babenkova2
1Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia. vtitov43@yandex.ru.
Abstract:
The concentrations of nitric oxide (NO) donors in the plasma of pregnant women with preeclampsia is several times higher than in healthy pregnant women. Antihypertensive drugs acting not through the NO-mediated mechanisms normalized BP in some women with preeclampsia, but did not significantly reduce the levels of NO donors in the plasma. It appears that preeclampsia is associated with insufficient NO availability for the targets, rather than low intensity of NO synthesis. The concentration of NO donor molecules in the plasma can therefore be a useful additional diagnostic marker of preeclampsia.
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