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A Programmable Handheld Extrusion-Based Bioprinting Platform for In Situ Skin Wounds Dressing: Balance Mobility and
Chenmin Wang1,2, Chengwei Hu1,3, Haojin Cheng1
1Research Center for Human Tissue and Organs Degeneration, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|October 22, 2024
Summary
This study introduces a smartphone-controlled handheld bioprinter for in situ wound dressing. This portable device enables precise, customizable bioprinting for effective skin wound repair, even in challenging environments.
Area of Science:
- Biotechnology
- Regenerative Medicine
- Medical Devices
Background:
- Bioprinting is vital for tissue substitutes, but clinical use is limited by scaffold mismatch and slow treatment.
- In situ bioprinting offers a solution by enabling direct application of bioregenerants within the body for targeted tissue repair.
Purpose of the Study:
- To develop a smartphone-controlled, handheld bioprinter for in situ skin wound dressing.
- To create a versatile device capable of precise, customizable bioprinting for complex wound management.
Main Methods:
- Development of a mini, handheld bioprinter controlled via smartphone application.
- Integration of programmable printing paths and bioink switching for heterogeneous structures.
- Optional attachment of microchannel needles for expanded functionality.
Main Results:
- The bioprinter can create various structures (strips, patterns, 3D) with programmed precision.
- The device allows for rapid, uniform coverage of large wound areas and effective filling of complex wounds.
- Demonstrated in vitro and in vivo efficacy in promoting wound healing.
Conclusions:
- The programmable handheld bioprinter offers a balance of mobility and customization for skin wound management.
- This technology holds potential for emergency medical treatment in resource-limited settings like disaster areas or battlefields.
