Predictive Value of Red Blood Cell Distribution Width-to-Platelet Ratio for Severity in Pyogenic Liver Abscess: A
Yunxiao Lyu1, Hao Wang1, Zhuojun Zhong1
1Department of Hepatobiliary Surgery, Dongyang People's Hospital; Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, P.R. China.
Abstract:
Background: The ratio of red blood cell distribution width (RDW) to platelet ratio (RPR) may have prognostic value in several inflammation-related diseases. However, few studies have been conducted on the value of RPR for predicting the severity of pyogenic liver abscess (PLA). Methods: Patients receiving the diagnosis of PLA from February 2013 to December 2022 were enrolled in this retrospective study. We collected data related to baseline characteristics and laboratory results within the first 24 hours the of admission. The receiver operating characteristic curve and the area under the curve (AUC) were used to evaluate the predictive ability of different indicators for severity in PLA. Results: A total of 278 patients were enrolled. For the prediction of sepsis in PLA, RPR had the highest AUC (0.83; 95% confidence interval [CI], 0.78-0.89) with a sensitivity of 0.78 and specificity of 0.82. For the prediction of septic shock, RPR also had the highest AUC (0.74; 95% CI, 0.60-0.88) with a sensitivity of 0.67 and specificity of 0.79. The best cutoff value for RPR to predict sepsis was 0.08 and to predict septic shock was 0.11. Conclusions: An increase in RPR level serves as a useful indicator with a predictive capacity for severity in PLA.
Insights
The red blood cell distribution width to platelet ratio (RPR) can predict the severity of pyogenic liver abscess (PLA). Higher RPR levels indicate a greater likelihood of sepsis or septic shock in PLA patients.
Area of Science:
- Hepatology
- Critical Care Medicine
- Clinical Pathology
Background:
- The prognostic value of the red blood cell distribution width (RDW) to platelet ratio (RPR) is recognized in various inflammation-related conditions.
- Limited research exists on the RPR's utility in predicting the severity of pyogenic liver abscess (PLA).
Purpose of the Study:
- To investigate the predictive capability of the RPR for assessing the severity of pyogenic liver abscess.
- To evaluate RPR's effectiveness in identifying sepsis and septic shock in PLA patients.
Main Methods:
- Retrospective analysis of 278 PLA patients diagnosed between February 2013 and December 2022.
- Collection of baseline characteristics and laboratory data within 24 hours of admission.
- Utilized receiver operating characteristic curve analysis and area under the curve (AUC) to assess predictive performance.
Main Results:
- RPR demonstrated the highest AUC (0.83) for predicting sepsis in PLA patients, with a sensitivity of 0.78 and specificity of 0.82.
- RPR also showed significant predictive value for septic shock (AUC=0.74), sensitivity of 0.67, and specificity of 0.79.
- Optimal RPR cutoff values were identified as 0.08 for sepsis and 0.11 for septic shock prediction.
Conclusions:
- The RPR is a valuable and accessible biomarker for predicting the severity of pyogenic liver abscess.
- Elevated RPR levels can serve as an early warning indicator for sepsis and septic shock in PLA patients, aiding clinical management.
