Association Between Body Composition Measured by Artificial Intelligence and Long-Term Sequelae After Acute...

Area of Science:

• Medical Science
• Gastroenterology
• Metabolic Diseases

Background:

• The role of body composition in acute pancreatitis (AP) complications is not well understood.
• Recurrence of AP and subsequent development of chronic pancreatitis (CP) or diabetes mellitus (DM) are significant concerns for patients.

Purpose of the Study:

• To investigate the association between body composition and the recurrence of AP.
• To explore the relationship between body composition and the development of CP and DM following AP.

Main Methods:

• Retrospective analysis of 347 patients with AP using CT imaging for body composition assessment.
• Automated segmentation algorithm used for analyzing subcutaneous adipose tissue (SAT), skeletal muscle (SM), and intermuscular adipose tissue (IMAT).
• Cox Proportional Hazards regression applied to identify predictors of recurrent AP, CP, and DM.

Main Results:

• Body composition metrics were not associated with recurrent AP.
• Obesity, body mass index, alcohol, and gallstone pancreatitis were associated with AP recurrence.
• Higher SAT correlated with lower CP incidence (unadjusted), while higher IMAT correlated with higher DM incidence (unadjusted).

Conclusions:

• Body composition does not predict recurrent AP.
• A significant proportion of patients developed CP (30.4%) and DM (25.0%) after AP.
• Specific adipose tissue depots (SAT, IMAT) showed differential associations with CP and DM development.