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Plasma Sqstm1/p62 Act As A Biomarker For Steroid-induced Osteonecrosis Of The Femoral Head.

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Plasma Sqstm1/p62 Act As A Biomarker For Steroid-induced Osteonecrosis Of The Femoral Head.

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Plasma SQSTM1/p62 act as a biomarker for steroid-induced osteonecrosis of the femoral head.

Wenyuan Hou¹, Peng Peng¹, Fangjun Xiao¹

¹Guangzhou University of Chinese Medicine, Guangzhou, China.

Scientific Reports

|October 22, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Plasma SQSTM1/p62 levels may help diagnose steroid-induced osteonecrosis of the femoral head (SIONFH). Lower levels indicate advanced SIONFH, offering potential for early detection.

Keywords:

Autophagy Collapse SQSTM1/p62 Steroid-induced necrosis of the femoral head

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Area of Science:

Biochemistry
Orthopedics
Cell Biology

Background:

Autophagy plays a key role in steroid-induced osteonecrosis of the femoral head (SIONFH) development and progression.
SQSTM1/p62 is a crucial indicator of cellular autophagic activity.

Purpose of the Study:

To investigate the role of SQSTM1/p62 in the pathogenesis of SIONFH.
To evaluate plasma SQSTM1/p62 as a potential biomarker for SIONFH staging.

Main Methods:

Recruited 36 SIONFH patients and 36 healthy controls.
Assessed SQSTM1/p62 expression in bone tissue and plasma.
Utilized imaging, pathologic assessment, and receiver operating characteristic (ROC) curves.

Main Results:

SQSTM1/p62 expression in bone decreased with increasing Association Research Circulation Osseous (ARCO) stage.

Plasma SQSTM1/p62 levels were significantly higher in SIONFH patients than controls.

Lower plasma SQSTM1/p62 levels correlated with advanced ARCO stages.

Conclusions:

Plasma SQSTM1/p62 may serve as a biomarker for SIONFH progression.
Decreased plasma SQSTM1/p62 levels are associated with advanced SIONFH stages.
This finding offers potential for the early diagnosis of SIONFH.