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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Microfluidic Device for Recreating a Tumor Microenvironment in Vitro
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Tumor-microenvironment-on-a-chip: the construction and application.

Hanzheng Xu1,2, Jiangtao Wen3, Jiahua Yang1

  • 1Department of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China.

Cell Communication and Signaling : CCS
|October 23, 2024
PubMed
Summary
This summary is machine-generated.

Tumor-microenvironment-on-chip (TMOC) platforms offer a novel way to study cancer by mimicking the in vivo tumor microenvironment. Further integration with tissue engineering could create better preclinical cancer models.

Keywords:
Cancer modelingIn vitro modelsMicrofluidicsTumor chipTumor microenvironment

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Area of Science:

  • Oncology
  • Biotechnology
  • Microfluidics

Background:

  • Cancer remains a leading cause of death globally, with treatment efficacy limited by tumor heterogeneity and the inability of current models to replicate the human tumor microenvironment.
  • Unclear molecular mechanisms of tumorigenesis and physiological complexity further impede the development of effective cancer therapies.

Purpose of the Study:

  • To review advancements in Tumor-Microenvironment-on-Chip (TMOC) platforms for cancer research.
  • To explore the applications of various TMOC types across different cancer models.
  • To discuss the future potential of TMOC as a refined preclinical cancer model.

Main Methods:

  • Integration of three-dimensional cell culture with microfluidic systems to create TMOC platforms.
  • Simulation of key components and physiological characteristics of the in vivo tumor microenvironment.
  • Review of existing literature on TMOC advancements and applications.

Main Results:

  • TMOC platforms provide a dynamic in vitro system that mimics the tumor microenvironment, enabling the study of tumor progression.
  • Diverse TMOC designs have been developed and applied to various cancer types.
  • Current TMOC platforms show promise for advancing cancer research.

Conclusions:

  • TMOC technology represents a significant step forward in simulating the tumor microenvironment for research.
  • Enhanced integration with tissue engineering and microphysiological systems is crucial for developing TMOC into a more refined preclinical model.
  • TMOC platforms hold potential for breakthroughs in understanding and treating cancer.