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Advancing Liposomal Coating Approaches for Improved Anticancer Drug Delivery
Ngoc Thuy Trang Le1,2, Anh-Minh Nguyen-Huu1, Dai Hai Nguyen2,3
1Institute of Applied Materials Science, Vietnam Academy of Science and Technology, 1B TL29 Thanh Loc Ward, District 12, Ho Chi Minh, Vietnam.
Chempluschem
|October 23, 2024
Summary
This study developed novel liposomes combining polyoxyethylene (100) stearyl ether and folic acid to improve quercetin delivery. These enhanced liposomes show improved anticancer efficacy and cellular uptake for potential cancer therapy applications.
Area of Science:
- Nanotechnology
- Pharmacology
- Oncology
Background:
- Quercetin, a flavonoid, possesses antioxidant, anti-inflammatory, and anticancer properties.
- Poor solubility and bioavailability limit quercetin's clinical use.
- Novel drug delivery systems are needed to enhance quercetin's therapeutic potential.
Purpose of the Study:
- To develop folate-conjugated polyoxyethylene (100) stearyl ether-coated liposomes (FA-Brij-LPs) for enhanced quercetin delivery.
- To improve quercetin's solubility, bioavailability, and targeted delivery for cancer therapy.
Main Methods:
- Liposomes were prepared using the thin-film hydration method.
- Physicochemical properties (size, zeta potential, drug loading) were characterized.
- In vitro studies assessed quercetin release, cellular uptake, and anticancer efficacy.
Main Results:
- Optimized FA-Brij-LPs showed a particle size of 147.57 nm, zeta potential of 32.20 mV, and drug loading of 9.33%.
- Sustained quercetin release and significantly enhanced cellular uptake were observed.
- FA-Brij-LPs demonstrated superior anticancer efficacy compared to free quercetin.
Conclusions:
- The developed FA-Brij-LPs effectively enhance quercetin delivery and efficacy.
- This novel delivery system holds promise for improving quercetin's application in cancer therapy.
- Combining polyoxyethylene (100) stearyl ether and folic acid is a viable strategy for quercetin delivery enhancement.
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