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Updated: Jun 9, 2025
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Cardiometabolic factors and vitamin D deficiency in pediatric patients with chronic kidney disease
Israel Parra-Ortega1, Jessie Nallely Zurita-Cruz2, Miguel Angel Villasis-Keever3
1Auxiliary Diagnostic Services, Hospital Infantil de México Federico Gómez, Ministry of Health (SSA), Mexico City, Mexico.
Insights
Vitamin D deficiency is linked to higher cholesterol and blood pressure in children with chronic kidney disease (CKD). This highlights the importance of monitoring vitamin D (VD) levels in pediatric CKD patients to manage cardiometabolic risks.
Area of Science:
- Pediatric Nephrology
- Endocrinology
- Cardiovascular Health
Background:
- Patients with chronic kidney disease (CKD) face elevated cardiovascular disease (CVD) risks.
- Inadequate vitamin D (VD) levels are prevalent in CKD patients and associated with cardiometabolic factors (CFs) in adults.
- Limited research exists on the VD-CF association in pediatric CKD populations.
Purpose of the Study:
- To investigate the impact of 25-hydroxyvitamin D3 (25-[OH]D) levels and status on cardiometabolic factors (CFs) in children undergoing kidney replacement therapy (KRT).
Main Methods:
- A cross-sectional study of 156 pediatric patients (aged 8-17) on hemodialysis or peritoneal dialysis.
- Evaluated anthropometrics, blood pressure, glucose, 25-(OH)D, and lipid profiles.
- Documented cholecalciferol supplementation and other relevant medications; statistical analyses included t-tests and chi-square tests.
Main Results:
- The average age was 12.9 years with a mean serum VD level of 22.5 ng/dL.
- Children with VD deficiency exhibited significantly higher total cholesterol and diastolic blood pressure (p < 0.05).
- No significant differences were observed in other biochemical markers or CF frequencies.
Conclusions:
- Vitamin D deficiency is associated with an increased risk of dyslipidemia and uncontrolled hypertension in pediatric end-stage CKD patients.
- These findings underscore the importance of assessing and managing VD status in children with CKD to mitigate cardiovascular risks.
Background:
Patients with chronic kidney disease (CKD) are at increased risk for cardiovascular disease. Up to 80% of patients with CKD may exhibit inadequate vitamin D (VD) levels, which have been linked to the presence of cardiometabolic factors (CFs) in the adult population. However, research on this association in the pediatric population is limited.
Objective:
To analyze the effects of 25-hydroxyvitamin D3 (25-[OH]D) levels and status on the presence of CFs in children receiving kidney replacement therapy (KRT).
Materials And Methods:
This cross-sectional study included pediatric patients receiving KRT, aged 8-17 years, who were receiving hemodialysis or peritoneal dialysis from January 2021 to March 2024. We conducted anthropometric measurements, blood pressure assessments, and glucose, 25-(OH)D, and lipid profiling for all participants. The daily dose of cholecalciferol supplementation, as well as other medications affecting bone and lipid metabolism and antihypertensive drugs, were documented. Statistical analyses were performed using Student's t-tests and chi-square tests to compare the CFs between groups with and without VD deficiency.
Results:
The study involved 156 patients with an average age of 12.9 years and a mean serum VD level of 22.5 ng/dL. Patients with VD deficiency presented higher levels of total cholesterol and diastolic blood pressure (p < 0.05). No statistically significant differences were found in other biochemical profile variables or in the frequency of cardiometabolic factors.
Conclusion:
Vitamin D deficiency seems to increase the risk of dyslipidemia and uncontrolled hypertension in children and adolescents with end-stage CKD.
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