Unveiling new chapters in medullary thyroid carcinoma therapy: advances in molecular genetics and targeted treatment

Related Experiment Video

Updated: Jun 9, 2025

Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

1.6K

Jia-Xuan Huai1,2, Fang Wang3, Wen-Hui Zhang1,2

  • 1Department of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

Frontiers in Endocrinology
|October 23, 2024
PubMed

Insights

Medullary Thyroid Carcinoma (MTC) is an aggressive thyroid cancer. This review covers MTC

Area of Science:

  • Oncology
  • Endocrinology
  • Molecular Genetics

Background:

  • Medullary Thyroid Carcinoma (MTC) originates from thyroid C-cells.
  • MTC is characterized by aggressive behavior and metastasis.
  • Early diagnosis and treatment present significant challenges.

Purpose of the Study:

  • To review recent molecular genetics findings in MTC.
  • To discuss advancements in precision therapies for MTC.
  • To explore novel biomarkers and their clinical implications.

Main Methods:

  • Comprehensive literature review of MTC research.
  • Analysis of molecular pathways, including RET and RAS genes.
  • Synthesis of data on therapeutic strategies and biomarkers.

Main Results:

  • Key insights into MTC pathogenesis from genetic studies.
  • Identification of evolving precision medicine approaches.
  • Emerging biomarkers for improved diagnosis and prognosis.

Conclusions:

  • Understanding MTC molecular genetics is crucial for targeted therapies.
  • Precision medicine and novel biomarkers are transforming MTC management.
  • Future research directions focus on clinical application and further discovery.
Keywords:
RAS genesRET genebiomarkersimmunotherapymedullary thyroid carcinomamolecular geneticsmulti-kinase inhibitorstargeted therapy

More Related Videos

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma07:01

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

21.0K
Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma06:08

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma

Published on: June 2, 2023

1.7K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.5K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
486
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K