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Clinical advances and challenges associated with TCR-T cell therapy for cancer treatment

Jianing Li1, Yongsheng Zhang2, Tong Fu3

  • 1Heilongjiang University of Chinese Medicine, Harbin, China.

Frontiers in Immunology
|October 23, 2024
PubMed
Abstract

Insights

T cell receptor (TCR)-T cell therapy shows significant promise in treating various cancers, especially blood cancers and some solid tumors. Combining TCR-T cell therapy with other immunotherapies further boosts anti-cancer effects.

Area of Science:

  • Oncology
  • Immunotherapy
  • Cell Therapy

Background:

  • T cell receptor (TCR)-T cell therapy is an emerging cancer immunotherapy.
  • The clinical trial landscape for TCR-T cell therapy in oncology is not well-defined.
  • This study provides a comprehensive analysis of registered TCR-T cell therapy trials.

Purpose of the Study:

  • To analyze the current status of clinical trials for TCR-T cell therapy in cancer treatment.
  • To identify trends and efficacy of TCR-T cell therapy across different cancer types.
  • To evaluate the impact of combination therapies involving TCR-T cell therapy.

Main Methods:

  • A systematic search of the Trialtrove database was performed for registered clinical trials up to August 1, 2024.
  • Trials focused on TCR-T cell therapy for oncological applications were included.
  • Statistical analysis of trial characteristics and efficacy data was conducted.

Main Results:

  • 174 eligible clinical trials were analyzed.
  • TCR-T cell therapy demonstrated significant efficacy in refractory hematologic malignancies and certain solid tumors.
  • Combination of TCR-T cell therapy with other immunotherapies enhanced anti-tumor activity.

Conclusions:

  • TCR-T cell therapy presents a promising avenue for cancer treatment.
  • Further research is needed to optimize treatment protocols and improve cost-effectiveness.
  • Enhancing efficacy and minimizing costs are key to realizing the full potential of this therapy.
Keywords:
TCR-T cell therapycancercancer immunotherapyclinical trialsgenetic engineeringtherapeutic resistance

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