Risk Factors for Early Post-transplant Weight Changes Among Simultaneous Pancreas-kidney Recipients and Impact on...

Area of Science:

• Nephrology
• Transplantation
• Metabolic Medicine

Background:

• Limited data exist on risk factors for weight changes post-simultaneous pancreas and kidney (SPK) transplantation.
• The association between significant weight changes and graft/metabolic outcomes in SPK recipients requires further investigation.

Purpose of the Study:

• To analyze risk factors for significant weight gain (SWG) and significant weight loss (SWL) within 6 months post-SPK transplant.
• To determine the association of SWG and SWL with graft and metabolic outcomes after SPK.

Main Methods:

• Retrospective analysis of 280 SPK recipients with functioning allografts for at least 6 months.
• Categorization based on weight change from baseline to 6 months post-transplant.
• Multivariate analysis to identify risk factors and outcome associations.

Main Results:

• 45% of SPK recipients experienced significant weight changes (20% SWG, 25% SWL).
• Older recipient age was associated with a decreased risk for SWG.
• Neither SWG nor SWL were linked to pancreas or kidney graft failure, but SWG showed a lower risk for composite adverse outcomes.

Conclusions:

• Significant weight changes are frequent in SPK recipients within 6 months post-transplant.
• Weight changes were not associated with adverse graft outcomes, likely due to effective management.
• SWG may be associated with improved composite outcomes post-SPK.