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Fulminant leptomeningeal disease diagnosed as comutant H3F3A and FGFR diffuse midline glioma

Larysa Benistant1, Damien Reita2, Maleka Schenck3

  • 1Oncology Department, Institut de Cancérologie Strasbourg Europe, 17 Avenue Albert Calmette, Strasbourg, France.

Annals of Clinical and Translational Neurology
|October 23, 2024
PubMed

Insights

This study reports a rare case of diffuse midline glioma with H3F3A and FGFR mutations presenting as leptomeningitis. Liquid biopsy proved crucial for diagnosing this challenging condition, especially with leptomeningeal spread.

Area of Science:

  • Neuro-oncology
  • Genetics
  • Pathology

Background:

  • Diffuse midline gliomas are rare and challenging brain tumors.
  • Leptomeningeal involvement complicates diagnosis and treatment.
  • Co-occurring H3F3A and FGFR mutations are uncommon in these gliomas.

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