Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Complementation Tests00:49

Complementation Tests

4.9K
A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
4.9K
Numerical Calculations01:24

Numerical Calculations

343
In engineering applications, the representation of the numerical value is critical. Presenting or reporting the answer is one of the essential parts of engineering practices. Numerical calculations are performed using handheld calculators or computers since numerically accurate answers are always preferred.
The solution to a problem is obtained using different methods. While manually solving algebraic symbols is one of the most common methods, the graphical method is often preferred. Computers...
343
Compacting Factor test01:22

Compacting Factor test

119
The compacting factor test is a method used to assess the workability of concrete. It is  especially suitable for concrete mixes containing aggregates up to one and a half inches in size. This test involves specialized equipment consisting of two truncated cone-shaped hoppers and a cylinder, all with polished interior surfaces to minimize friction.
The procedure begins by placing concrete into the upper hopper without any compaction. Once filled, the bottom door of this hopper is opened,...
119
Accuracy, limits, and approximation01:28

Accuracy, limits, and approximation

441
Accuracy, limits, and approximations are common in many fields, especially in engineering calculations. These concepts are imperative for ensuring that a given value is as close as possible to its true value.
Accuracy is defined as the closeness of the measured value to the true or actual value. In engineering mechanics, repeated measurements are taken during theoretical or experimental analyses to ensure that the result is precise and accurate.
The accuracy of any solution is based on the...
441
Sign Test for Nominal Data01:12

Sign Test for Nominal Data

71
The sign test is a nonparametric method used to evaluate hypotheses about the median of a single sample or to compare the medians of two related samples. The sign test is particularly useful when dealing with nominal data, which includes distinct categories without an inherent order, such as names, labels, and preferences. Nominal data restricts statistical analysis to evaluating population proportions rather than mean or median values that require continuous data.
For example, consider a...
71
Sound Waves: Resonance01:14

Sound Waves: Resonance

2.5K
Resonance is produced depending on the boundary conditions imposed on a wave. Resonance can be produced in a string under tension with symmetrical boundary conditions (i.e., has a node at each end). A node is defined as a fixed point where the string does not move. The symmetrical boundary conditions result in some frequencies resonating and producing standing waves, while other frequencies interfere destructively. Sound waves can resonate in a hollow tube, and the frequencies of the sound...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A prematurely terminated phase 2, randomised trial to evaluate immunogenicity and reactogenicity of a single versus two-dose primary vaccination regimen of the mRNA vaccine BNT162b2 in previously SARS-CoV-2 infected children 5-11 years old (CoVacc trial).

Vaccine·2026
Same author

Impact of Information Leakage in Platform Trials With Survival Endpoints on Type I Error Control.

Pharmaceutical statistics·2026
Same author

On the Inclusion of Non-Concurrent Controls in Platform Trials With an Interim Analysis.

Statistics in medicine·2026
Same author

Extremity Ultrasound vs. Computed Tomography at the Third Lumbar Vertebra Level for Assessing the Subcutaneous Adipose Tissue-to-Muscle Ratio.

Nutrients·2026
Same author

Design and analysis of randomized clinical trials for onchocerciasis, loiasis and mansonellosis: A systematic review.

PLoS neglected tropical diseases·2026
Same author

Comparison of primary analysis strategies of randomized controlled trials with multiple endpoints with application to kidney transplantation.

Scientific reports·2026
Same journal

Regression analysis of misclassified current status data with potentially unknown test accuracy.

Statistical methods in medical research·2026
Same journal

Bayesian multivariate linear mixed-effects models with varied association structures.

Statistical methods in medical research·2026
Same journal

Inference about the ratio of age-standardized rates between two overlapping populations.

Statistical methods in medical research·2026
Same journal

A robust neural network with random effects for subject-specific prediction of clustered count data.

Statistical methods in medical research·2026
Same journal

A comparison of methods for designing hybrid type 2 cluster-randomized trials with continuous effectiveness and implementation endpoints.

Statistical methods in medical research·2026
Same journal

Joint analysis of longitudinal and recurrent event data: A functional regression approach with autoregressive frailty.

Statistical methods in medical research·2026
See all related articles

Related Experiment Video

Updated: Jun 9, 2025

fMRI Mapping of Brain Activity Associated with the Vocal Production of Consonant and Dissonant Intervals
11:15

fMRI Mapping of Brain Activity Associated with the Vocal Production of Consonant and Dissonant Intervals

Published on: May 23, 2017

7.2K

A general consonance principle for closure tests based on p-values.

Sonja Zehetmayer1, Franz Koenig1, Martin Posch1

  • 1Center for Medical Data Science, Medical University of Vienna, Austria.

Statistical Methods in Medical Research
|October 23, 2024
PubMed
Summary
This summary is machine-generated.

This study enhances closed testing procedures for multiple hypotheses by improving consonant tests. Simulations show these modified tests significantly increase statistical power for familywise error rate control.

Keywords:
Combination testFisher combination testStouffer testclosed testmultiple testing

More Related Videos

Author Spotlight: Validation of SICOLE-R for Assessing Cognitive and Reading Skills in Spanish-Speaking Children and Its Role in Personalized Education
09:00

Author Spotlight: Validation of SICOLE-R for Assessing Cognitive and Reading Skills in Spanish-Speaking Children and Its Role in Personalized Education

Published on: August 16, 2024

709
Using Eye Movements Recorded in the Visual World Paradigm to Explore the Online Processing of Spoken Language
09:27

Using Eye Movements Recorded in the Visual World Paradigm to Explore the Online Processing of Spoken Language

Published on: October 13, 2018

9.9K

Related Experiment Videos

Last Updated: Jun 9, 2025

fMRI Mapping of Brain Activity Associated with the Vocal Production of Consonant and Dissonant Intervals
11:15

fMRI Mapping of Brain Activity Associated with the Vocal Production of Consonant and Dissonant Intervals

Published on: May 23, 2017

7.2K
Author Spotlight: Validation of SICOLE-R for Assessing Cognitive and Reading Skills in Spanish-Speaking Children and Its Role in Personalized Education
09:00

Author Spotlight: Validation of SICOLE-R for Assessing Cognitive and Reading Skills in Spanish-Speaking Children and Its Role in Personalized Education

Published on: August 16, 2024

709
Using Eye Movements Recorded in the Visual World Paradigm to Explore the Online Processing of Spoken Language
09:27

Using Eye Movements Recorded in the Visual World Paradigm to Explore the Online Processing of Spoken Language

Published on: October 13, 2018

9.9K

Area of Science:

  • Statistical methodology
  • Hypothesis testing
  • Biostatistics

Background:

  • The closure principle offers efficient methods for controlling familywise error rate (FWER) in strong sense.
  • Closed tests utilize p-value combination tests for intersection hypotheses, but some lack consonance.

Purpose of the Study:

  • To develop a general principle for uniformly improving closed tests based on p-value combination tests.
  • To ensure consonant procedures where global null rejection implies elementary null rejection.

Main Methods:

  • Investigated closed tests using various p-value combination tests (Fisher, Stouffer, Omnibus, etc.).
  • Developed a principle to modify rejection regions for improved consonance.
  • Conducted simulations to compare power of new and existing methods.

Main Results:

  • Identified non-consonant combination tests (Fisher, Stouffer, Omnibus).
  • Demonstrated that modified closed tests become consonant.
  • Simulations revealed substantial power increases for Fisher and Stouffer combination tests.

Conclusions:

  • The proposed principle effectively enhances closed testing procedures.
  • Modified closed tests offer improved statistical power while maintaining FWER control.
  • This advancement is particularly beneficial for statistical analyses with multiple hypotheses.