Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ikbel Ghachem1, Lamine Hamzaoui2, Asma Bachali1

  • 1Medical analysis laboratory, Mohamed Taher Maamouri Hospital, Nabeul. Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis,Tunisia.

La Tunisie Medicale
|October 23, 2024
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Assessment of liver fibrosis in Chronic hepatitis B: performance of hematological parameters.

La Tunisie medicale·2026
Same author

Gastrointestinal bleeding due to portal hypertension in cirrhosis: Prognostic value of the CAGIB score.

La Tunisie medicale·2026
Same author

Assessing Medical Knowledge Gaps on Transfusion Incidents and Preventive Strategies.

La Tunisie medicale·2026
Same author

La Tunisie medicale·2026
Same author

La Tunisie medicale·2026
Same author

Helicobacter pylori eradication rate following first line non-bismuth quadruple therapy regimen in Tunisian patients: the HPERAD study.

BMC infectious diseases·2025
Same journal

Abstracts International Scientific Day on Oxidative Stress, Aging, and Age-Related Diseases.

La Tunisie medicale·2026
Same journal

Pharmacological evaluation of anti-inflammatory potential and antispasmodic effect of aqueous extract from the brown seaweed, Cystoseira compressa.

La Tunisie medicale·2026
Same journal

Assessing the Accuracy of LDL-Cholesterol Estimation Formulas in the Tunisian Population.

La Tunisie medicale·2026
Same journal

Association between Oxidative Stress, Cardiovascular Risk, and Disease Activity in Patients with Spondyloarthritis: A Cross-Sectional Study in a Tunisian Cohort.

La Tunisie medicale·2026
Same journal

Assessment of oral cancer awareness among dentists in Tunisia: A cross-sectional study.

La Tunisie medicale·2026
See all related articles

Non-invasive tests for liver fibrosis in chronic hepatitis B (CHB) patients were evaluated. The GGT-to-platelet ratio (GPR) showed comparable performance to APRI and FIB-4, but no significant advantages were found.

Area of Science:

  • Hepatology and Gastroenterology
  • Biomarker Discovery
  • Diagnostic Accuracy Studies

Context:

  • Percutaneous liver biopsy (PLB) is invasive; non-invasive tests (NIT) are sought for liver fibrosis prediction.
  • Chronic hepatitis B (CHB) is a global health concern requiring accurate fibrosis staging.
  • Evaluating diagnostic performance of NIT in a specific patient population is crucial.

Purpose:

  • To assess the diagnostic performance of several NITs for liver fibrosis in Tunisian CHB patients.
  • To compare the accuracy of APRI, GPR, FIB-4, and RPR against the Metavir score.

Summary:

  • The study evaluated APRI, GPR, FIB-4, and RPR in 77 Tunisian CHB patients.
  • GPR demonstrated high accuracy for significant and advanced fibrosis, comparable to APRI.
Keywords:
chronic hepatitis Bgamma-glutamylliver fibrosisnon-invasive biomarkertranspeptidase to-platelet ratio

Related Experiment Videos

  • While GPR showed promise, multivariate analysis indicated APRI, FIB-4, and GPR as independent predictors for different fibrosis stages, with FIB-4 being a strong predictor for cirrhosis.

    • Impact:

    • Provides comparative performance data for multiple NITs in a CHB cohort.
    • Highlights the potential utility of GPR, APRI, and FIB-4 in non-invasively assessing liver fibrosis.
    • Informs clinical practice regarding the selection of appropriate non-invasive markers for CHB management.