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Dhouha Nefzi1, Lotfi Chaabani1, Arij Jouini1

  • 1Ophthalmology Department, Kasserine Regional Hospital. Faculty of Medicine of Sousse, University of Sousse, Tunisia.

La Tunisie Medicale
|October 23, 2024
PubMed
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Optical coherence tomography angiography (OCTA) revealed reduced peripapillary vascular density in optic neuropathies, particularly in non-arteritic anterior ischemic optic neuropathy. Hypertension independently correlated with these microvascular damages.

Area of Science:

  • Ophthalmology
  • Neuro-ophthalmology
  • Medical Imaging

Background:

  • Optic neuropathies encompass diverse conditions affecting the optic nerve.
  • Peripapillary microvasculature plays a crucial role in optic nerve health.
  • Assessing microvascular changes can aid in understanding disease progression.

Purpose of the Study:

  • To describe and analyze peripapillary microvascular alterations in various optic neuropathies.
  • To investigate the utility of optical coherence tomography angiography (OCTA) in visualizing these changes.
  • To identify factors associated with peripapillary microvascular damage.

Main Methods:

  • A cross-sectional observational study involving 63 eyes with optic neuropathy and 36 healthy controls.
  • Evaluation using optical coherence tomography (OCT) and OCTA.
Keywords:
Eyeangiographyoptic neuropathyoptical coherence tomography

Related Experiment Videos

  • Data collected between January 2018 and December 2018.

    • Main Results:

    • Acute non-arteritic anterior ischemic optic neuropathy (NAION) showed more vascular changes than optic neuritis.
    • Optic atrophy was associated with capillary rarefaction and reduced peripapillary vascular density (PVD).
    • Positive correlation between visual acuity and PVD in NAION and chronic retrobulbar optic neuritis (NORB); inverse correlation with disease duration. Hypertension was linked to microvascular damage.

    Conclusions:

    • OCTA demonstrated reduced PVD and increased vascular changes in acute NAION compared to optic neuritis.
    • Reduced PVD was observed at the atrophic stage of optic neuropathy.
    • Hypertension emerged as an independent risk factor for peripapillary microvascular damage.