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Microfluidics in Assessing Platelet Function

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Potential Predictive Value of Platelet Distribution Width for Functional Outcome After Ischemic Stroke.

Tong Shen¹, Junfen Fan¹, Yangmin Zheng¹

¹Institute of Cerebrovascular Diseases Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing, 100053, China.

Molecular Neurobiology

|October 23, 2024

Summary

Platelet distribution width (PDW) shows a causal link to poor functional outcomes after ischemic stroke. While higher PDW levels correlate with worse outcomes, its predictive value may be indirect, possibly related to glucose levels.

Keywords:

Complete blood cell count Functional outcome Ischemic stroke Mendelian randomization

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Area of Science:

Genetics
Neurology
Hematology

Background:

Complete blood cell count (CBC) is a common lab test.
Observational studies suggest links between CBC indices and ischemic stroke, but causality is unclear.

Purpose of the Study:

To investigate the causal relationships between CBC indices and functional outcomes (modified Rankin Scale score) 3 months post-ischemic stroke.
To explore the role of platelet distribution width (PDW) in stroke prognosis.

Main Methods:

Two-sample Mendelian randomization (TSMR) using UK Biobank data for blood traits (n=350,475) and GISCOME network data for ischemic stroke outcomes (n=6021).
Complementary analyses and a clinical cohort validation (n=351) were performed.

Main Results:

TSMR revealed a causal association between genetically determined PDW and adverse functional outcomes after ischemic stroke (OR 1.48, P=0.005).
Higher PDW levels were observed in patients with unfavorable outcomes in the cohort study.
PDW showed positive correlation with serum glucose and was higher in non-thrombolysed patients, suggesting indirect involvement in prognosis.

Conclusions:

Genetically determined PDW has a causal effect on poor functional outcomes following ischemic stroke.
PDW's role in stroke prognosis appears indirect, potentially mediated by factors like serum glucose levels.