Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Search research articles

Home
Research Domains
Biomedical And Clinical Sciences
Oncology And Carcinogenesis
Predictive And Prognostic Markers
Clinical Significance Of Cd155 Expression In Surgically Resected Lung Squamous Cell Carcinoma.

Home
Research Domains
Biomedical And Clinical Sciences
Oncology And Carcinogenesis
Predictive And Prognostic Markers
Clinical Significance Of Cd155 Expression In Surgically Resected Lung Squamous Cell Carcinoma.

Related Experiment Video

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Published on: May 11, 2016

Clinical significance of CD155 expression in surgically resected lung squamous cell carcinoma.

Taichi Nagano¹, Kazuki Takada², Asato Hashinokuchi¹

¹Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

International Journal of Clinical Oncology

|October 23, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

High CD155 expression in lung squamous cell carcinoma (LUSC) indicates a poor prognosis, particularly in patients with PD-L1 positive tumors. This finding highlights CD155 as a potential therapeutic target for LUSC immunotherapy.

Keywords:

CD155 Lung cancer PD-L1 Prognostic factor

More Related Videos

Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

Published on: August 14, 2019

A Three-dimensional Model of Spheroids to Study Colon Cancer Stem Cells

A Three-dimensional Model of Spheroids to Study Colon Cancer Stem Cells

Published on: January 22, 2021

Related Experiment Videos

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Published on: May 11, 2016

Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

Published on: August 14, 2019

A Three-dimensional Model of Spheroids to Study Colon Cancer Stem Cells

A Three-dimensional Model of Spheroids to Study Colon Cancer Stem Cells

Published on: January 22, 2021

Area of Science:

Oncology
Immunology
Pathology

Background:

Cluster of differentiation 155 (CD155) is implicated in tumor immune evasion and progression.
CD155's role in lung squamous cell carcinoma (LUSC) and its prognostic significance remain underexplored.
CD155 presents a potential target for novel cancer immunotherapies.

Purpose of the Study:

To investigate the clinical significance of CD155 expression in surgically resected LUSC.
To evaluate the association between CD155 expression, clinicopathological features, and patient outcomes.
To explore the relationship between CD155 expression, PD-L1 status, and tumor-infiltrating lymphocytes.

Main Methods:

Retrospective analysis of 264 patients with surgically resected LUSC.

Squamous cell carcinoma

Immunohistochemistry to assess CD155 expression levels.

Statistical analysis to correlate CD155 expression with clinicopathological variables, PD-L1 expression, and survival outcomes.

Main Results:

High CD155 expression was observed in 51.9% of LUSC patients and correlated with pleural/vascular invasion and PD-L1 positivity.
High CD155 expression was an independent predictor of poor overall survival in multivariate analysis.
The negative prognostic impact of CD155 was significant in PD-L1 positive tumors but not in PD-L1 negative tumors.

Conclusions:

Elevated CD155 expression is a significant indicator of poor prognosis in LUSC patients.
CD155 may serve as a valuable prognostic biomarker, especially in combination with PD-L1 status.
Targeting CD155 could be a promising strategy for LUSC immunotherapy, particularly in PD-L1 positive subsets.