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Anisotropic Hollow Structure with Chemotaxis Enabling Intratumoral Autonomic Therapy.

Ping Hou^1,2, Lingeng Xie^3,4, Ludan Zhang^3,5

¹State Key Laboratory of Biochemical Engineering Key Laboratory of Biopharmaceutical Preparation and Delivery Institute of Process Engineering, Chinese Academy of Sciences, 1 North 2nd Street, Zhongguancun, Haidian District, Beijing, 100190, P. R. China.

Angewandte Chemie (International Ed. in English)

|October 23, 2024

Summary

Researchers developed smart, glucose-seeking hollow nanostructures for targeted cancer drug delivery. These anisotropic hollow multishell structures (a-HoMS) improve drug penetration and release, enhancing antitumor efficacy through repeated cycles.

Keywords:

chemotaxis drug delivery hollow structure porous structure temporal-spatial ordering

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Microfluidic Device for Recreating a Tumor Microenvironment in Vitro

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Area of Science:

Biomaterials Science
Nanotechnology
Cancer Therapy

Background:

Effective intratumoral drug penetration is crucial for cancer treatment but hindered by poor tumor perfusion.
Current strategies face challenges in achieving autonomous directional drug delivery and controlled release within tumors.

Purpose of the Study:

To engineer novel asymmetrical hollow structures with glucose-dependent chemotaxis for enhanced intratumoral drug delivery.
To improve drug penetration, cellular uptake, and targeting precision in solid tumors.

Main Methods:

Design and synthesis of anisotropic hollow multishell structures (a-HoMS) inspired by glucose specificity in tumors.
Incorporation of multiple shells to enhance local chemical concentration gradients and improve diffusion and directivity.
Evaluation of a-HoMS movement, drug release kinetics, and sequential delivery capabilities.

Main Results:

a-HoMS exhibited significantly increased diffusion coefficient (73.4%) and directivity (273%) compared to isotropic spheres.
Multi-level porosity enabled sequential drug delivery, inhibiting angiogenesis and inducing apoptosis.
a-HoMS demonstrated autonomous migration to residual tumor cells for repeated drug delivery cycles, achieving excellent antitumor efficacy.

Conclusions:

Anisotropic hollow multishell structures offer intelligent, adaptable, and precise tumor therapy.
These structures provide a promising platform for programmable drug delivery within tumor tissues.
The glucose-guided chemotaxis and sequential release mechanism enhance overall therapeutic outcomes.