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Updated: Jun 9, 2025
Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
Published on: June 6, 2025
Plasma Profiling of Acute Myeloid Leukemia With Fever- and Infection-Related Complications During
Iris C Kreft1, Annemarie van de Geer2,3, Eva R Smit1
1Department of Molecular Hematology, Sanquin Research, Amsterdam, The Netherlands.
Background:
Acute myeloid leukemia (AML) is a heterogenous and complex blood cancer requiring aggressive treatment. Early identification and prediction of the complications following treatment is vital for effective disease management.
Aims:
We explored associations between plasma protein levels and fever- and infection-related complications in 26 AML patients during chemotherapy-induced neutropenia.
Material And Methods:
Longitudinal plasma profiling was conducted using data-dependent mass spectrometry analysis.
Results:
Mass spectrometry-based plasma profiling data correlated well with laboratory parameters, including C-reactive protein, and revealed a broader inflammation protein network associated with fever- and infection-related complications.
Discussion And Conclusion:
These data indicate the potential of longitudinal plasma profiling in AML patients for identifying and predicting complications that may aid in improved disease monitoring and treatment.
