New criteria to predict LATE-NC in the clinical setting: Probable/Possible LATE and LANS
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View abstract on PubMed
Summary
This summary is machine-generated.New terminology for dementia classification, including limbic-predominant age-related TDP-43 encephalopathy (LATE), is evolving. This review clarifies distinctions between clinical syndromes, biomarkers, and pathological definitions for aging-associated TDP-43 proteinopathy.
Area Of Science
- Neurology
- Pathology
- Geriatrics
Background
- Aging-associated TDP-43 proteinopathy is a significant cause of dementia.
- Limbic-predominant age-related TDP-43 encephalopathy (LATE) and limbic-predominant amnestic neurodegenerative syndrome (LANS) are recently proposed classifications.
- LATE neuropathologic changes (LATE-NC) are the current gold standard for diagnosis.
Purpose Of The Study
- To review and discuss new terminology for dementia classification, specifically for aging-associated TDP-43 pathology.
- To emphasize the need for clear distinctions between clinical, biomarker, and pathological disease concepts.
- To assess the evolving clinical utility of proposed criteria for LATE.
Main Methods
- Literature review of recent proposals for dementia and LATE/LANS classification.
- Analysis of the distinctions between clinical syndromes, molecular biomarkers, and pathological definitions.
- Discussion of the implications of evolving biomarker research for clinical diagnosis.
Main Results
- Newly proposed clinical rubrics for LATE and LANS are presented.
- The importance of precise terminology differentiating clinical presentation, biomarker evidence, and pathological confirmation is highlighted.
- The definitions of "Probable" and "Possible" LATE are expected to gain clinical relevance with advancements in biomarker research.
Conclusions
- The evolving terminology aims to better define aging-associated TDP-43 proteinopathy.
- Clear distinctions between clinical syndromes and pathological entities are crucial for accurate diagnosis and research.
- For neuropathological diagnosis and basic research, terminology for LATE-NC remains unchanged by the new clinical criteria.
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