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Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
Sequential One-Pot Transformation to R-CF2-Embedded 1,5-Diketones Enabled by Nickel: Access to
Lalit Mohan Kabadwal1, Shuvojit Haldar1, Debasis Banerjee1
1Laboratory of Catalysis and Organic Synthesis, Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247667, India.
Abstract:
Herein, we have demonstrated the application of bench-stable polyfluorinated alcohols as fluoroalkylating reagents for a sequential one-pot transformation with ketones to R-CF2-embedded 1,5-diketones and pyridines enabled by a nickel catalyst. The protocol is tolerant to a range of functional groups (>31 examples and up to 85% yield) and perfluoro alcohols and releases H2 and H2O as byproducts. Preliminary mechanistic studies, EPR analyses, and deuterium scrambling experiments were performed, and observed PC-H/PC-D = 2.12.
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