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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
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Identifying disruptive papers in pharmacy literature that changed clinical practice: 1954-2014
Adan Z Becerra1, Leslie Kam1, Yoona Kim1
1Arine, Inc., San Francisco, CA, USA.
Summary
A new disruption score metric identified landmark pharmacy research papers that significantly impacted clinical practice. This metric offers a unique view of scientific impact beyond traditional citation counts.
Area of Science:
- Bibliometrics
- Pharmacy Practice Research
Background:
- Identifying influential research is crucial for advancing pharmacy practice.
- Traditional metrics like citation counts may not fully capture a paper's impact on clinical practice.
Purpose of the Study:
- To identify research publications that have significantly influenced clinical practice in pharmacy.
- To introduce and utilize a novel metric, the disruption score, for assessing research impact.
Main Methods:
- Bibliometric analysis of pharmacy practice articles from 11 key journals and PubMed.
- Utilized a validated dataset of disruption scores for articles published between 1954 and 2014.
- Identified top 100 most disruptive and most cited papers, comparing lists and journals.
Main Results:
- The top 100 most disruptive papers exceeded the disruption level of 99.9% of all PubMed articles.
- The 1990s emerged as the most disruptive decade for pharmacy research.
- American Journal of Health-System Pharmacy published the most disruptive articles; a weak correlation was found between disruption score and citation count.
Conclusions:
- The disruption score effectively identifies landmark papers with a lasting legacy in pharmacy practice.
- This metric provides a unique perspective on clinical significance, complementing existing bibliometric indices.
- The disruption score aids in recognizing papers that have introduced new paradigms in pharmacy.
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