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Microdissection and Whole Mount Scanning Electron Microscopy Visualization of Mouse Choroid Plexus
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Choroid Plexus Volume in Pediatric-Onset Multiple Sclerosis.

Eleonora A Grasso1, Luke Bloy1, Phillip Kaplan1

  • 1From the Departments of Neurology (E.A.G., P.K., B.L.B.), Radiology (L.B.), Children's Hospital of Philadelphia, PA; Department of Neurology (A.B.-O.), University of Pennsylvania, PA; Division of Neurology (E.A.Y.), The Hospital for Sick Children, Toronto, Canada; McConnell Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, Montreal, Canada; Department of Neurology (S.N.), McGill University, Montreal, Canada; Departments of Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; and Department of Medicine (G.F.), University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Canada.

Neurology(R) Neuroimmunology & Neuroinflammation
|October 23, 2024
PubMed
Summary
This summary is machine-generated.

Children with pediatric-onset multiple sclerosis (MS) have larger choroid plexus volumes (CPV) at diagnosis than healthy children. This increased CPV did not predict disease activity or disability in the first year of MS.

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Area of Science:

  • Neuroimmunology
  • Pediatric Neurology
  • Neuroimaging

Background:

  • The choroid plexus (CP) is implicated in central nervous system (CNS) inflammation in multiple sclerosis (MS).
  • Pediatric-onset MS (POMS) exhibits significant inflammatory activity, making it a relevant model for studying early inflammatory changes.

Purpose of the Study:

  • To compare choroid plexus volume (CPV) in children with POMS versus healthy controls (HCs).
  • To assess changes in CPV during the first year of POMS.
  • To investigate associations between CPV, brain volumes, disease activity, and disability in POMS.

Main Methods:

  • 1.5T MRI scans were analyzed for 23 POMS participants and 23 HCs, with 18 POMS participants having 12-month follow-up scans.
  • Manual segmentation was used to determine CPV, normalized for intracranial volume.
  • Correlations were examined between CPV and brain/lesion volumes, relapse rates, and Expanded Disability Status Scale (EDSS) scores.

Main Results:

  • Normalized CPV was significantly greater in POMS participants (1.51 × 10-3) compared to HCs (1.21 × 10-3; p=0.001).
  • CPV did not significantly change over the first year in POMS participants (p=0.352).
  • CPV correlated with lateral ventricular volume but not with brain volumes, T2 lesions, relapse activity, or EDSS scores.

Conclusions:

  • Baseline CPV is elevated in children with POMS compared to HCs.
  • Elevated baseline CPV does not appear to predict disease activity or neurological outcomes within the first year of POMS.
  • While increased CPV may indicate early inflammation in MS, its correlation with ventricular volume warrants further investigation.