Decreasing Trends of Traumatic Brain Injury Despite a Surge in Anticoagulant Use in the Elderly
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View abstract on PubMed
Summary
This summary is machine-generated.Elderly patients on anticoagulants have higher mortality after traumatic brain injury (TBI), despite decreasing TBI admissions. Anticoagulant use is rising in this population, but mortality trends remain stable.
Area Of Science
- Geriatric Trauma
- Neurocritical Care
- Pharmacovigilance
Background
- Rising anticoagulant use in elderly patients coincides with TBI risk.
- Anticoagulants are increasingly prescribed for elderly individuals, a demographic vulnerable to traumatic brain injury (TBI).
- This study investigates the impact of anticoagulant use on TBI outcomes in older adults.
Purpose Of The Study
- To assess trends in anticoagulant use among elderly trauma patients.
- To evaluate the association between prehospital anticoagulant use and TBI outcomes, including mortality and admission rates.
- To analyze changes in TBI-related mortality in elderly patients on anticoagulants over time.
Main Methods
- Retrospective analysis of 5 years (2017-2021) of data from the Trauma Quality Improvement Program.
- Inclusion of trauma patients aged 65 years and older, with identification of those with TBI.
- Utilized linear regression for trend analysis and propensity score matching (1:1) to compare anticoagulant users versus non-users.
Main Results
- A significant decrease in TBI admissions was observed over the study period (P < 0.001).
- Prehospital anticoagulant use significantly increased (P = 0.043).
- Propensity score-matched analysis revealed higher mortality in TBI patients who used anticoagulants prehospitalization (9.1% vs. 6.8%, P < 0.001).
Conclusions
- Increasing anticoagulant use in the elderly is linked to higher mortality after TBI.
- Despite rising anticoagulant use, TBI admissions have decreased in the elderly population.
- Mortality trends in elderly TBI patients on anticoagulants remained largely unchanged over the study period.
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