Related Experiment Video
Updated: Jun 9, 2025
Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
Published on: March 21, 2021
Evaluation of a fully automated computed tomography image segmentation method for fast and accurate body composition
Michelle V Dietz1, Karteek Popuri2, Lars Janssen1
1Department of Surgical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Introduction:
Body composition evaluation can be used to assess patients' nutritional status to predict clinical outcomes. To facilitate reliable and time-efficient body composition measurements eligible for clinical practice, fully automated computed tomography segmentation methods were developed. The aim of this study was to evaluate automated segmentation by Data Analysis Facilitation Suite in an independent dataset.
Materials And Methods:
Preoperative computed tomography images were used of 165 patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy from 2014 to 2019. Manual and automated measurements of skeletal muscle mass (SMM), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and intramuscular adipose tissue (IMAT) were performed at the third lumbar vertebra. Segmentation accuracy of automated measurements was assessed using the Jaccard index and intra-class correlation coefficients.
Results:
Automatic segmentation provided accurate measurements compared to manual analysis, resulting in Jaccard score coefficients of 94.9 for SMM, 98.4 for VAT, 99.1 for SAT, and 79.4 for IMAT. Intra-class correlation coefficients ranged from 0.98 to 1.00. Automated measurements on average overestimated SMM and SAT areas compared to manual analysis, with mean differences (±2 standard deviations) of 1.10 (-1.91 to 4.11) and 1.61 (-2.26 to 5.48) respectively. For VAT and IMAT, automated measurements on average underestimated the areas with mean differences of -1.24 (-3.35 to 0.87) and -0.93 (-5.20 to 3.35), respectively.
Conclusions:
Commercially available Data Analysis Facilitation Suite provides similar results compared to manual measurements of body composition at the level of third lumbar vertebra. This software provides accurate and time-efficient body composition measurements, which is necessary for implementation in clinical practice.
