Photodynamic therapy: An emerging therapeutic modality in dentistry
Nandita Suresh1, Betsy Joseph2, Pradeesh Sathyan3
1Department of Oral and Maxillofacial Diseases, Helsinki University and University Hospital, Helsinki, Finland; Pushpagiri Institute of Medical Sciences and Research Centre, Mendicity, Perumthuruthy, Tiruvalla, Kerala, India.
Bioorganic & Medicinal Chemistry
|October 23, 2024
Summary
Photodynamic therapy (PDT) offers a promising, non-invasive approach to dental treatments, showing potential for conditions like periodontal disease and oral cancer. Further research is needed to integrate this advanced therapy into routine dental practice.
Area of Science:
- Dental pharmacotherapeutics
- Non-invasive treatment modalities
Background:
- Photodynamic therapy (PDT) is an evolving non-invasive treatment.
- PDT utilizes light-activated compounds for therapeutic effects.
Purpose of the Study:
- To comprehensively review the principles, applications, and future perspectives of PDT in dentistry.
- To evaluate the benefits and challenges of PDT for various dental conditions.
Main Methods:
- Literature review of current research on PDT in dentistry.
- Analysis of PDT applications in periodontics, endodontics, oral cancer, dental implants, and caries.
- Discussion of advantages, challenges, and future directions.
Main Results:
- PDT demonstrates selective targeting, broad-spectrum antimicrobial effects, and no resistance development.
- Applications span periodontal disease, endodontics, oral cancer, implants, and caries.
- Challenges include photosensitizer delivery, light penetration, and oxygen availability.
Conclusions:
- PDT holds significant potential to revolutionize dental pharmacotherapeutics.
- Further high-quality research is essential for clinical integration.
- PDT offers a promising, less invasive treatment option for diverse dental conditions.
