Electrochemical biosensor based on copper sulfide/reduced graphene oxide/glucose oxidase construct for glucose...

Area of Science:

• Electrochemistry
• Materials Science
• Biomedical Engineering

Background:

• Diabetes mellitus is a growing global health concern requiring effective blood glucose monitoring.
• Electrochemical sensors offer sensitive and real-time glucose detection capabilities.
• Reduced graphene oxide (rGO) and transition metal sulfides show promise for enhanced sensor performance due to their unique properties.

Purpose of the Study:

• To develop and evaluate a novel electrochemical sensor for sensitive and selective glucose detection.
• To investigate the synergistic effects of copper sulfide (CuS) and reduced graphene oxide (rGO) in an electrochemical sensing platform.
• To explore the electrocatalytic performance of a CuS/rGO modified electrode for glucose oxidation.

Main Methods:

• Fabrication of a modified glassy carbon electrode (GCE) using flake graphite, copper sulfate, and glucose oxidase (GOx) to form a CuS/rGO/GOx/GCE.
• Electrochemical characterization and performance evaluation of the fabricated sensor for glucose detection.
• Investigation of the sensing mechanism and dynamic processes involved in glucose electrocatalysis.

Main Results:

• The CuS/rGO/GOx/GCE sensor exhibited a low detection limit of 1.75 nM and a wide linear range of 0.1-100 mM for glucose.
• The sensor demonstrated excellent selectivity, anti-interference capabilities, and good repeatability and reproducibility.
• The study successfully investigated the sensing mechanism and dynamic processes of the electrode for glucose detection.

Conclusions:

• The developed CuS/rGO/GOx/GCE sensor provides a highly effective platform for accurate and reliable blood glucose monitoring.
• The synergistic integration of CuS and rGO significantly enhances the electrochemical sensing performance for glucose.
• This sensor technology holds practical potential for improving diabetes management and patient care.