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TNF receptors: Structure-function relationships and therapeutic targeting strategies

Chih Hung Lo1

  • 1Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore; Department of Biology, Syracuse University, NY 13244, USA; Interdisciplinary Neuroscience Program, Syracuse University, NY 13244, USA.

Biochimica Et Biophysica Acta. Biomembranes
|October 23, 2024
PubMed
Summary

Tumor necrosis factor receptors (TNFR1 and TNFR2) are crucial in inflammation and cell death, implicated in various diseases. Targeting their structure and conformational states offers new therapeutic strategies for autoimmune disorders, neurodegenerative diseases, and cancers.

Keywords:
AntibodyConformational dynamicsConformational statesDrug discoveryFRET biosensorPeptideReceptor-ligand interactionReceptor-receptor interactionSmall moleculeTNF receptor

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