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Updated: Jun 9, 2025

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
11:14

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

1.5K

Clues into Wnt cell surface signalosomes and its biogenesis

Philip Schmiege1, Xiaochun Li1

  • 1Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Trends in Biochemical Sciences
|October 23, 2024
PubMed

Insights

Recent studies reveal how Wnt morphogens bind receptors Frizzled (FZD) and LRP5/6. The research also explores Cachd1 as an alternative Wnt signaling initiator and the secretion of lipidated Wnt.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Structural Biology

Background:

  • Wnt morphogens are crucial signaling molecules.
  • Understanding Wnt receptor interactions is key to deciphering developmental and disease pathways.

Purpose of the Study:

  • To review recent structural insights into Wnt-receptor binding.
  • To highlight alternative Wnt signaling initiation mechanisms.
  • To discuss the biogenesis and secretion of lipidated Wnt.

Main Methods:

  • Structural biology analyses
  • Biochemical assays
  • Cellular imaging techniques

Main Results:

  • Detailed structures of Wnt engagement with Frizzled (FZD) and LRP5/6 receptors.
  • Evidence for Cachd1 as an alternative initiator of Wnt signaling.
  • Insights into the post-translational modification and secretion of Wnt proteins.

Conclusions:

  • Structural data provides a mechanistic basis for Wnt receptor activation.
  • Cachd1 represents a novel node in Wnt pathway regulation.
  • Understanding Wnt lipidation is essential for comprehending signaling dynamics.
Keywords:
Cachd1LRPPORCNWntless (WLS)calreticulin (CALR)frizzled (FZD)

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