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Related Experiment Video

Updated: May 5, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Bitolterol mesylate in exercise-induced asthma.

S B Walker, C W Bierman, W E Pierson

    The Journal of Allergy and Clinical Immunology
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Bitolterol mesylate effectively prevents exercise-induced asthma by significantly reducing FEV1 decline. This beta-adrenergic agent offers a promising therapeutic option compared to isoproterenol and placebo.

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    Area of Science:

    • Pulmonology
    • Pharmacology
    • Exercise Physiology

    Background:

    • Exercise-induced asthma (EIA) is a common condition.
    • EIA serves as a model for studying asthma pharmacotherapy.
    • Evaluating bronchodilator efficacy in EIA is clinically significant.

    Purpose of the Study:

    • To assess the efficacy of aerosolized bitolterol mesylate in preventing EIA.
    • To compare bitolterol mesylate's protective effects against isoproterenol and placebo.
    • To determine the duration of action and side effect profile of bitolterol mesylate in EIA.

    Main Methods:

    • Double-blind, crossover study design.
    • Twelve subjects with EIA underwent cycloergometer exercise.
    • Administration of bitolterol mesylate (1050 µg), isoproterenol (255 µg), or placebo via aerosol 45 minutes prior to exercise.

    Main Results:

    • Bitolterol mesylate significantly attenuated the maximal decrease in FEV1 post-exercise (5.0%) compared to isoproterenol (22.2%) and placebo (23.2%).
    • Skeletal muscle tremor was reported in four subjects using bitolterol mesylate and three using isoproterenol.
    • No other significant adverse effects were observed with bitolterol mesylate.

    Conclusions:

    • Aerosolized bitolterol mesylate is highly effective in preventing exercise-induced bronchoconstriction.
    • Bitolterol mesylate demonstrates superior efficacy over isoproterenol in this EIA model.
    • Bitolterol mesylate presents a favorable safety profile for managing EIA.