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Factors Associated With Abdominal Pain in Patients With Active and Quiescent Ulcerative Colitis: A Multicohort Study
Tom van Gils1, Hans Törnblom1, Jóhann P Hreinsson1
1Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Alimentary Pharmacology & Therapeutics
|October 24, 2024
Summary
Abdominal pain is common in ulcerative colitis (UC) patients, affecting quality of life. Anxiety, active disease, and female sex are linked to this pain, suggesting a holistic treatment approach.
Area of Science:
- Gastroenterology
- Inflammatory Bowel Disease Research
- Clinical Medicine
Background:
- Abdominal pain is frequently underestimated in ulcerative colitis (UC) management.
- Understanding pain prevalence and associated factors is crucial for effective UC patient care.
Purpose of the Study:
- To determine the prevalence of abdominal pain in both active and quiescent ulcerative colitis (UC).
- To identify factors associated with abdominal pain in UC patients across different disease states.
Main Methods:
- Analysis of three adult UC patient cohorts (two cross-sectional, one longitudinal).
- Utilized the Gastrointestinal Symptom Rating Scale for pain assessment.
- Employed validated questionnaires for psychological distress, fatigue, and quality of life (QoL).
Main Results:
- Abdominal pain reported by 58-63% of active UC patients versus 33-54% of quiescent UC patients.
- Pain decreased significantly from diagnosis (71%) to remission (46%) in the longitudinal cohort.
- Anxiety symptoms, active disease, and female sex were associated with increased abdominal pain; lower QoL correlated with higher pain levels.
Conclusions:
- Abdominal pain is prevalent in ulcerative colitis (UC), impacting QoL regardless of disease activity.
- Key associated factors include active disease, female sex, and psychological distress, particularly anxiety.
- A comprehensive, holistic approach is recommended for managing UC patients experiencing abdominal pain.
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