Related Experiment Video
Updated: Jun 9, 2025
15:29
Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells
Published on: August 5, 2016
8.2K
Predictive Significance of Laboratory Tests in Bacteremic Brucellosis
Mehmet Çelik1, Yeliz Çiçek2, Ebru Atalay3
1Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, University of Harran, Şanlıurfa, Turkey.
Iranian Journal of Public Health
|October 24, 2024
Summary
High ferritin levels and low eosinophil counts can help predict Brucella bacteremia when blood cultures are negative. These laboratory findings are crucial for diagnosing this common zoonotic infection.
Area of Science:
- Infectious Diseases
- Microbiology
- Clinical Diagnostics
Background:
- Brucellosis is a prevalent zoonotic infection with diagnostic challenges.
- Blood culture, the gold standard, may yield false negatives.
- Predictive markers for bacteremia in brucellosis are needed.
Purpose of the Study:
- To identify demographic, clinical, and laboratory factors predicting bacteremia in brucellosis patients.
- To evaluate the significance of various laboratory parameters in diagnosing Brucella bacteremia.
Main Methods:
- Retrospective multicenter study of 743 brucellosis patients (2012-2022).
- Patients categorized into bacteremic and non-bacteremic groups.
- Demographic, clinical, and laboratory data analyzed, including ROC analysis for ferritin.
Main Results:
- Bacteremic patients were younger with more frequent fever, chills, sweating, nausea, vomiting, and weight loss.
- Lower WBC, platelet, hemoglobin, MPV, eosinophil, and neutrophil counts observed in bacteremic group.
- Higher lymphocyte, ESR, AST, ALT, LDH, and ferritin levels were associated with bacteremia, with ferritin > 67 being highly predictive.
Conclusions:
- Elevated ferritin, decreased eosinophils, and increased ESR are key indicators of Brucella bacteremia.
- These findings aid in diagnosing brucellosis bacteremia, especially when cultures are inconclusive.
Related Concept Videos
01:30Pneumonia III: Complications and Assessment
174
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
174
01:26Pulmonary Tuberculosis IV
134
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
134