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Articles linked to this work by shared authors, journal, and citation graph.

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ESTRO recommendations for the use, planning and delivery of reirradiation in locally recurrent rectal cancer - Endorsed by ASTRO.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
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[Reirradiation: A new therapeutic paradigm in oncology].

Bulletin du cancer·2026
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Study Protocol of OLIGOPELVIS 2-GETUG P12: A Randomized Phase 3 Study Comparing Intermittent Androgen-deprivation Therapy with or Without Salvage High-dose Intensity-modulated Radiotherapy to Oligorecurrent Pelvic and Para-aortic Lymph Nodes in Patients with Biochemically Relapsing Prostate Cancer.

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Magnetic resonance imaging-guided radiotherapy for prostate cancer: A systematic review of the literature.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2026
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Breast Cancer Reirradiation Practice Patterns: An International Survey From the Reirradiation Collaborative Group (ReCOG).

Practical radiation oncology·2026
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In Reply to DeLaney.

International journal of radiation oncology, biology, physics·2026
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Exploration of the radiation dose-toxicity relationship for multiple ophthalmological organs at risk for pediatric patients assessed in long-term head and neck rhabdomyosarcoma survivors.

Clinical and translational radiation oncology·2026
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Skin Cosmesis assessment tools and methods in patients with non-melanoma skin cancers treated with radiotherapy: Systematic review on behalf of the ESTRO skin and soft tissue focus group and the GEC-ESTRO head and neck and skin working group.

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Role of radiotherapy in refractory/relapsed classical Hodgkin lymphoma in the era of targeted therapies and immunotherapy.

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Moving beyond anatomy: the future of rectal cancer management is biologically-informed, response-adapted, and patient-centered.

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Organ preservation in rectal cancer following clinical complete response after short-course radiotherapy-based total neoadjuvant therapy.

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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
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Reirradiation - still navigating uncharted waters?

Nicolaus Andratschke1, Jonas Willmann1, Ane L Appelt2,3

  • 1Department of Radiation Oncology, University Hospital of Zurich, University of Zurich, Switzerland.

Clinical and Translational Radiation Oncology
|October 24, 2024
PubMed
Summary
This summary is machine-generated.

Reirradiation, using advanced radiotherapy, offers new hope for cancer patients. However, balancing tumor control with normal tissue toxicity requires standardized reporting and more evidence for safe clinical practice.

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Area of Science:

  • Radiation Oncology
  • Medical Physics
  • Clinical Oncology

Background:

  • High-precision radiotherapy advances enable reirradiation for recurrent or metastatic cancers.
  • A significant challenge in reirradiation is managing cumulative radiation dose to normal tissues, balancing tumor control and toxicity.
  • Current clinical practice relies heavily on expertise due to scarce prospective evidence and non-standardized study reporting.

Purpose of the Study:

  • To summarize current evidence on reirradiation.
  • To identify knowledge gaps in reirradiation research.
  • To explore best practices for safe reirradiation.

Main Methods:

  • An international, interdisciplinary expert meeting was convened on June 15, 2023, in Zurich.
  • The meeting was endorsed by SASRO, DEGRO, and ESTRO.
  • Discussions focused on available evidence and research priorities in reirradiation.

Main Results:

  • Advanced radiotherapy technologies are making reirradiation a viable option.
  • Standardized reporting and quality evidence are crucial for safe reirradiation protocols.
  • Expert consensus highlighted the need for further research and standardized guidelines.

Conclusions:

  • Reirradiation is increasingly feasible due to technological advancements.
  • Addressing toxicity risks and standardizing reporting are critical for advancing reirradiation.
  • Further research and evidence generation are essential for optimizing reirradiation strategies.